October 16, 2019
October 19, 2019
AddressMont Sainte-Odile monastery, Alsace, France View map
This international meeting covers various aspects of the biology of lipid second messengers. It mostly encompasses topics related to the phosphoinositides (PIs) and their soluble counterparts, the inositol phosphates.
Over the last few years, many reports have extended our knowledge of the inositol lipid metabolism and brought out some exciting information about the location, the variety and the role of PIs. Several of these quantitatively minor components of the membranes and intracellular organelles are implicated in the control of diverse cellular processes including cytoskeleton remodelling, cellular proliferation and survival, vesicular trafficking and motility. Their metabolism is strictly controlled by the interplay of phospholipases (phospholipase C), kinases (PI 3-kinases, ..) and phosphatases (the tumour suppressor PTEN, SHIP, ..) that are regulated and/or relocated through cell surface receptors, therefore leading to a PI response to extracellular cues. This feature of PIs, which can be rapidly synthesized and degraded in discrete subcellular domains (membrane domains, sub-nuclear structures) places them as ideal integrators of very dynamic mechanisms of cell regulation. Moreover, several PI-binding domains (PH, FYVE, PX, ENTH, etc…) have been identified, pointing out to the importance of these lipids as scaffolds recruiting specific effectors to orchestrate the spatiotemporal organization of key signalling pathways. Therefore, it is not surprising that several of their regulatory enzymes are closely linked to human diseases (cancer, genetic disease, bacterial and viral infection), and are of great interest for the biomedical research field. There are multiple ongoing clinical trials targeting PI-kinases in several pathologies. This meeting will have a special emphasis on the implication of inositol lipids and phosphates and their metabolizing enzymes in diseases and in the development of therapeutic strategies. This represents a very topical, active and promising field.